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    CAR-T cells

    CAR-T cells

    CAR-T therapy is an immunotherapy that uses gene engineering technologies such as viral vectors or electroporation to implant chimeric antigen receptors (CARs) that specifically recognize tumor-associated antigens and simultaneously activate T cells into the patient's T lymphocytes. These CAR-T cells are then purified and expanded in vitro before being reinfused, allowing them to inhibit and kill tumors. Shenzhen Cell Cell Technology Co., Ltd. provides R&D and outsourced production services for CAR-T cells targeting different targets. Currently, it has successfully used its self-produced industrial-grade retroviral vectors to prepare multiple CAR-T cells targeting CD19, CD38, and BCMA-CD38 dual targets, with transduction efficiencies exceeding 70%. The company can provide a complete service from T lymphocyte collection, transduction of tumor-targeting viral vectors, CAR-T cell expansion, safety testing, and release. Currently, it provides GMP-grade CAR-T cell production services to institutions such as Huazhong University of Science and Technology and Shenzhen Hospital.
    Description
    Overview
    •  CAR-T therapy is an immunotherapy that uses gene engineering technologies such as viral vectors or electroporation to implant chimeric antigen receptors (CARs) that specifically recognize tumor-associated antigens and simultaneously activate T cells into the patient's T lymphocytes. These CAR-T cells are then purified and expanded in vitro before being reinfused, allowing them to inhibit and kill tumors. • Shenzhen Cell Cell Technology Co., Ltd. can provide R&D and outsourced production services for CAR-T cells targeting different targets . Currently, it has successfully used its self-produced industrial-grade retroviral vectors to prepare multiple CAR-T cell lines targeting CD19, CD38, and BCMA-CD38 dual targets , with transduction efficiencies exceeding 70%. It can complete the entire process from T lymphocyte collection, transduction of tumor-targeting viral vectors , CAR-T cell expansion, safety testing, and release. Currently, it provides GMP-grade CAR-T cell production services to institutions such as Huazhong University of Science and Technology Union Hospital and Shenzhen Hospital.

    Production process

    GMP-grade CAR-T cell industrial production process


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    Shenzhen Cell Valley Biopharmaceutical Co., Ltd.​​ is a comprehensive one-stop outsourcing service provider in China focused on the cell and gene therapy industry. It is also one of the first CRO/CDMO companies in the country to possess GMP industrial production capabilities for clinical-grade retroviral vectors . The company is a major public technical service platform construction project for CRO/CDMO in Shenzhen and is included among the city's latest announced "20+8" strategic emerging industry projects.Shenzhen Cell Valley has the capability for standardized and industrialized production of GMP-grade cell products such as CAR-T cells. Its primary production lines include those for various cell products like CAR-T, CAR-NK, CAR-M, γδT, TIL, and TCR-T. Additionally, the company operates production lines for various viral vectors, including RVV, LVV, non-viral vectors, and AAV, as well as for cellular raw materials used in producing therapeutics such as exosomes, genetically engineered antibodies, cytokines, oncolytic viruses, and vaccines.
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