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Adeno-associated virus vector

Adeno-associated virus vector

Adeno-associated viruses (AAVs) are a class of simple, non-enveloped, single-stranded DNA-deficient viruses capable of infecting both dividing and non-dividing cells. They can package large genes, making them a preferred tool for gene overexpression. AAVs are characterized by good safety, a broad host cell range, low immunogenicity, and long-term expression of exogenous genes in vivo. Shenzhen Cell Valley provides adeno-associated virus vectors of various specifications and serotypes, including single-promoter single-gene, single-promoter multi-gene, and dual-promoter multi-gene subtypes.
Description

Highlights

1. High safety and low pathogenicity to humans;
2. Infectious on both dividing and non-dividing cells;
3. Effectively proliferates;
4. High viral titer.

Overview

•  Adeno-associated virus (AAV) is a member of the parvoviridae family. It is a type of non-replicating, non-enveloped, icosahedral microvirus with a diameter of approximately 20-26 nm, containing about 4.7 kb of linear single-stranded DNA as its genome. The recombinant adeno-associated virus (rAAV)vectoris a gene vector modified from non-pathogenic wild-typeAAV. Due to its diversity, extremely low immunogenicity, high safety, broad host cell range (infecting both dividing and non-dividing cells), strong dispersibility, and long in vivo gene expression time, rAAVisconsidered one of the most promising vectors for gene research and gene therapy.

AAV genome structure


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Contact：Ms. Lai

Email：laijiaqi@aicaocy.com

Address：No. 1, Rongtian Road, Jinsha Community, Kengzi Street, Pingshan District, Shenzhen, China (Hepure Biomedical Ecological Park)

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Shenzhen Cell Valley Biopharmaceutical Co., Ltd.​​ is a comprehensive one-stop outsourcing service provider in China focused on the cell and gene therapy industry. It is also one of the first CRO/CDMO companies in the country to possess GMP industrial production capabilities for clinical-grade retroviral vectors . The company is a major public technical service platform construction project for CRO/CDMO in Shenzhen and is included among the city's latest announced "20+8" strategic emerging industry projects.Shenzhen Cell Valley has the capability for standardized and industrialized production of GMP-grade cell products such as CAR-T cells. Its primary production lines include those for various cell products like CAR-T, CAR-NK, CAR-M, γδT, TIL, and TCR-T. Additionally, the company operates production lines for various viral vectors, including RVV, LVV, non-viral vectors, and AAV, as well as for cellular raw materials used in producing therapeutics such as exosomes, genetically engineered antibodies, cytokines, oncolytic viruses, and vaccines.
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